ABSTRACT DNA from hundreds of ancient humans remains spanning the last 7000 years has been sequenced over the past few years in the “Southern Arc” region of West Asia and surrounds. Using DNA we here investigate the demographic changes that occurred over the past 2000 years in the Anatolia region as they pertain to the …
The PEOPLING OF ANATOLIA OVER THE PAST 2000 YEARS Read More »
abstract To date there has been very limited analysis on Asian population histories using whole genome sequencing (WGS). Most population history genetics studies only utilize a few hundred thousand SNPs, which is small fraction of the genetic variation in humans. This small fraction of the genetics variation is ascertained using certain populations. An example are …
Genetic Relationships of Asian Populations using Whole Genome Sequencing Read More »
Sometime between the late Bronze-Age and the early Iron-Age, Iran experienced a linguistic and population replacement. Approximately 2700 years ago, the Indo-Iranian Medes established the Median empire which stretched from north-west Pakistan westwards to Turkey, and thereby brought genetic, linguistic, as well as ideological changes to Iran. Although not much is known about this period …
ABSTRACT The flood of recently sequenced ancient DNA has tremendously increased our understanding of demography of various Eurasian modern populations. Thanks to the recently sequenced genomes in Damgaard et al, Narasimhan et al, Olaide et al, Lazaridis et al, and Mathieson et al, and the suite of tools within Admixtools, detailed in Patterson et al …
Impact of the Iron Age Saka and Scythians on the demography of Kurds Read More »
BACKGROUND Over the past decade various tools have been developed for ancient DNA analysis and assessing shared drift between populations. Some programs such as STRUCTURE, ADMIXTURE are allele frequency based. Others such as Reich Lab’s ADMIXTOOLS use both allele frequencies as well as direct allele comparisons. Others yet such as IBS and IBD compared genomes …
In progress: A method for improving accuracy in specific shared drift tests Read More »
OVERVIEW The overwhelming majority of published ancient DNA (aDNA) are pseudo-haploid genomes. This study focuses on the suitability and accuracy of these pseudo-haplodized aDNA genomes for various types of downstream analysis, such as those involving admixture allele frequency studies, as well as Identity-by-Decent (IBD) analyses and analyses using formal methods. The accuracy of pseudo-haploid aDNA …
Diploid Genotyping Low to Medium Coverage Ancient DNA – Part 1 Read More »
A new paper by Liu et al1 examines patterns of genetic diversity and positive natural selection, and finds that populations predominantly located in South Asia underwent considerably different adaptation as compared with populations from the other geographical regions. Here is their abstract: “The Asian Diversity Project (ADP) assembled 37 cosmopolitan and ethnic minority populations in …